Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial

• DOI: 10.1172/jci.insight.178460
• Publication Date: 2024-04-23T14:22:17Z
• Authors: Han-Sol Park; Anna Yin; Caelan Barranta; John S. Lee; Christopher A. Ca...; Jaiprasath Sachit...; Maggie Li; Steve Yoon; Ioannis Sitaras; Anne Jedlicka; Yolanda Eby; Malathi Ram; Reinaldo E. Ferna...; Owen R. Baker; Aarthi G. Shenoy; Giselle S. Mosnaim; Yuriko Fukuta; Bela Patel; Sonya L. Heath; Adam C. Levine; Barry R. Meisenberg; Emily S. Spivak; Shweta Anjan; Moises A. Huaman; Janis E. Blair; Judith S. Currier; James H. Paxton; Jonathan M. Gerber; Joann R. Petrini; Patrick B. Broderick; William Rausch; Marie Elena Cordisco; Jean Hammel; Benjamin Greenblatt; Valerie C. Cluzet; Daniel Cruser; Kevin Oei; Matthew Abinante; Laura L. Hammitt; Catherine G. Sutc...; Donald N. Forthal; Martin S. Zand; Edward R. Cachay; Jay S. Raval; Seble G. Kassaye; Christi E. Marshall; Anusha Yarava; Karen Lane; Nichol A. McBee; Amy L. Gawad; Nicky Karlen; Atika Singh; Daniel E. Ford; Douglas A. Jabs; Lawrence J. Appel; David M. Shade; Bryan Lau; Stephan Ehrhardt; Sheriza N. Baksh; Janna R. Shapiro; Jiangda Ou; Yu Bin Na; Maria D. Knoll; Elysse Ornelas-Ga...; Netzahualcoyotl A...; Thomas J. Gniadek; Patrizio Caturegli; Jinke Wu; Nelson Ndahiro; Michael J. Betenb...; Alyssa Ziman; Daniel F. Hanley; Arturo Casadevall; Shmuel Shoham; Evan M. Bloch; Kelly A. Gebo; Aaron A.R. Tobian; Oliver Laeyendecker; Andrew Pekosz; Sabra L. Klein; David J. Sullivan
• Keywords: Convalescent plasma; 2019-20 coronavirus outbreak

BACKGROUND. COVID-19 convalescent plasma (CCP) virus-specific antibody levels that translate into recipient posttransfusion sufficient to prevent disease progression are not defined.