Siglec-G represses DAMP-mediated effects on T cells

• DOI: 10.1172/jci.insight.92293
• Publication Date: 2017-07-19T15:22:28Z
• Authors: Tomomi Toubai; Corinne Rossi; Katherine Oravecz...; Cynthia Zajac; Chen Liu; Thomas Braun; Hideaki Fujiwara; Julia Wu; Yaping Sun; Stuart Brabbs; Hiroya Tamaki; John Magenau; Pang Zheng; Yang Liu; Pavan Reddy
• Keywords: SIGLEC; Damp

The role of negative regulators or suppressors the damage-associated molecular pattern-mediated (DAMP-mediated) stimulation innate immune responses is being increasingly appreciated. However, presence and function DAMP-mediated effects on T cells, whether they can be targeted to mitigate cell-dependent immunopathology remain unknown. Sialic acid-binding immunoglobulin-like lectin G (Siglec-G) a regulator in but its cell-autonomous Utilizing loss-of-function-based (genetic knockout) gain-of-function-based (agonist) approaches, we demonstrate that certain DAMPs, Siglec-G suppressed vitro vivo cell responses. We also critical for modulating severity cell-mediated immunopathology, graft-versus-host disease (GVHD). Enhancing signaling donor cells with agonist, CD24Fc fusion protein, ameliorated GVHD while preserving sufficient graft-versus-tumor (GVT) vivo. Collectively, these data potentially novel responses, which GVHD.