Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals.

• DOI: 10.1172/jci112908
• Publication Date: 2008-02-28T19:49:45Z
• Authors: S Izumo; A M Lompré; R Matsuoka; G Koren; K Schwartz; B Nadal-Ginard; V Mahdavi
• Keywords: Pressure overload

Expression of the cardiac myosin isozymes is regulated during development, by hormonal stimuli and hemodynamic load. In this study, levels expression two isoforms (alpha beta) heavy chain (MHC) hypertrophy were investigated at messenger RNA (mRNA) protein levels. normal control sham-operated rats, alpha-MHC mRNA predominated in ventricular myocardium. response to aortic coarctation, there was a rapid induction beta-MHC followed appearance comparable parallel an increase left weight. Administration thyroxine coarctated animals caused deinduction alpha-MHC, both levels, despite progression hypertrophy. These results suggest that MHC isozyme transition overload mainly pretranslational mechanisms, complex interplay exists between gene expression.