Alveolar epithelial cell chemokine expression triggered by antigen-specific cytolytic CD8+ T cell recognition

• DOI: 10.1172/jci9786
• Publication Date: 2008-02-19T19:13:50Z
• Authors: Min Q. Zhao; Mark H. Stoler; Angela N. Liu; Beiyang Wei; Carolina Soguero; Young S. Hahn; Richard I. Enelow
• Keywords: Adoptive Cell Transfer

CD8+ T lymphocyte responses are a critical arm of the immune response to respiratory virus infection and may play role in pathogenesis interstitial lung disease. We have shown that cells induce significant injury absence by adoptive transfer into mice with alveolar expression viral transgene. The is characterized parenchymal infiltration host cells, primarily macrophages, which correlates physiologic deficits transgenic animals. cell–mediated can occur perforin Fas as long TNF-α available. Here, we show effect expressed mediated not exclusively cytotoxicity, but also through activation target their inflammatory mediators. cell recognition vitro triggered monocyte chemoattractant protein-1 (MCP-1) macrophage protein-2 (MIP-2) targets, was TNF-α. Antigen-dependent MCP-1 observed vivo early 3 hours after depended upon TNF-R1 recipients. neutralization significantly reduced transfer. conclude epithelial actively participate inflammation associated antigens.