Changes in depressive symptoms as AIDS develops. The Multicenter AIDS Cohort Study

• DOI: 10.1176/ajp.153.11.1430
• Publication Date: 2014-12-17T19:50:12Z
• Authors: Constantine G. Ly...; Donald R. Hoover; M Guccione; Mary Amanda Dew; Jerry Wesch; Eric G. Bing; Glenn J. Treisman
• Keywords: Depression

The authors sought to determine whether rates of depressive symptoms change from early- late-stage HIV-1 infection and the predictors as AIDS develops.The data for this study were 911 HIV-seropositive men-community volunteers four U.S. cities-who entered 10-year Multicenter Cohort Study without a diagnosis subsequently developed AIDS. subjects underwent semiannual follow-ups during period. outcome measures-overall symptoms, nonsomatic syndromal depression, severe depression-were assessed over 5 years before 2 after responses on Center Epidemiologic Studies Depression Scale (CES-D Scale).Depressive stable time month 60 18 developed. However, beginning 12-18 months diagnosis, there was significant rise in all measures which reached plateau within 6 At plateau, 45% increase mean CES-D scores above baseline. An elevated score earlier stages infection, self-report AIDS-related (such rash lymphadenopathy), concurrent unemployment, cigarette smoking, limited social supports consistent higher depression developed.There is dramatic, sustained develops, early clinical diagnosed. Prior HIV-disease-related factors, psychological stressors contribute rise. This robust phenomenon invites further characterization.