Evidence for a Locus on Chromosome 1 That Influences Vulnerability to Alcoholism and Affective Disorder

• DOI: 10.1176/appi.ajp.158.5.718
• Publication Date: 2002-10-11T18:10:43Z
• Authors: John I. Nurnberger; Tatiana Foroud; Leah Flury; Jessica Su; Eric T. Meyer; Kuolung Hu; Raymond Crowe; Howard Edenberg; Alison Goate; Laura Bierut; Theodore Reich; Marc Schuckit; Wendy Reich
• Keywords: Vulnerability

OBJECTIVE: Depression (major depression or depressive syndrome) is more prevalent in alcoholic than nonalcoholic subjects families with multiple members alcoholism studied as part of the Collaborative Study on Genetics Alcoholism (National Institute Alcohol Abuse and Alcoholism). First-degree relatives probands comorbid have a higher prevalence both disorders alone, groups comparison selected without regard to psychopathology. Data from collaborative study were used test three phenotypes (comorbid depression, depression) for genetic linkage. METHOD: Genome-wide sibling-pair linkage analyses performed syndrome). Analyses two data sets (initial replication sets) subject ascertained identical criteria, well combined set. RESULTS: Peak lod scores chromosome 1 (near 120 centimorgan) phenotype 5.12, 1.52, 4.66 initial, replication, sets, respectively. The corresponding 2 2.79, 0.20, 3.26; 6, they 3.39, 0.00, 0.92; 16, 3.13, 2.06. Lod 4.12, 2.16, CONCLUSIONS: results suggest that gene genes may predispose some individuals others (which be alcohol induced). Loci other chromosomes also interest.