Prospective Long-Term Follow-Up of 44 Patients Who Received Cingulotomy for Treatment-Refractory Obsessive-Compulsive Disorder

• DOI: 10.1176/appi.ajp.159.2.269
• Publication Date: 2002-10-11T18:20:39Z
• Authors: Darin D. Dougherty; Lee Baer; G. Rees Cosgrove; Edwin H. Cassem; Bruce H. Price; Andrew A. Nierenberg; Michael A. Jenike; Scott L. Rauch
• Keywords: Refractory (planetary science); Depression

OBJECTIVE: Long-term outcome associated with cingulotomy for obsessive-compulsive disorder (OCD) was prospectively assessed. Findings are reported 18 patients previously described in 1995 and 26 new patients. METHOD: An open preoperative follow-up assessment conducted at multiple time points 44 undergoing one or more cingulotomies treatment-refractory OCD. The were assessed by using the Structured Clinical Interview DSM-III-R preoperatively Yale-Brown Obsessive Compulsive Scale, Beck Depression Inventory, Sickness Impact Profile both all assessments. completed clinical global improvement scales RESULTS: At mean of 32 months after cingulotomies, 14 (32%) met criteria treatment response six others (14%) partial responders. Thus, 20 (45%) least responders long-term cingulotomies. Few adverse effects reported. CONCLUSIONS: Thirty-two percent to 45% unresponsive medication behavioral treatments OCD partly improved cingulotomy. Cingulotomy remains a viable option severe