Diminished Suppression of the P50 Auditory Evoked Potential in Bipolar Disorder Subjects With a History of Psychosis

• DOI: 10.1176/appi.ajp.162.1.43
• Publication Date: 2004-12-30T01:58:53Z
• Authors: Ann Olincy; Laura Martin
• Keywords: Bipolar illness; Bipolar I disorder

OBJECTIVE: People with schizophrenia, schizoaffective disorder, and bipolar illness share clinical symptoms, biological findings, genetic susceptibility. Diminished suppression of the P50 auditory evoked potential is a phenotype used in studies susceptibility schizophrenia. In patients acute mania, this inhibitory deficit has been correlated severity symptoms. This study addresses whether diminished represents associated psychosis illness. METHOD: The response to paired stimuli was measured 64 subjects Structured Clinical Interview for DSM-IV life chart determined diagnosis. Beck Depression Inventory, Young Mania Rating Scale, Positive Negative Syndrome Scale current Groups were compared previously collected data from 36 schizophrenia 42 healthy subjects. RESULTS: significantly differed between disorder lifetime history without did not differ that Severity symptoms correlate suppression. CONCLUSIONS: A longitudinal potential. may represent common physiological mechanism vulnerability people as well