Cosegregation of Bipolar Disorder and Autosomal-Dominant Medullary Cystic Kidney Disease in a Large Family

• DOI: 10.1176/appi.ajp.162.10.1972
• Publication Date: 2005-09-30T23:52:45Z
• Authors: Ryan J. Kimmel; Ildiko Kovacs; Cathy Vrabel; Barry Wood; Martin Schalling; John R. Kelsoe
• Keywords: Genetic Markers; Male; Bipolar Disorder; Models, Genetic; Genetic Linkage; Chromosome Mapping; Comorbidity; Polycystic Kidney, Autosomal Dominant; Pedigree; 3. Good health; 03 medical and health sciences; Phenotype; 0302 clinical medicine; Chromosomes, Human, Pair 1; Humans; Female; Genetic Predisposition to Disease; Chromosomes, Human, Pair 16

The authors report a large family in which bipolar disorder appears to cosegregate with autosomal-dominant medullary cystic kidney disease.Information regarding diagnostic criteria for and disease were gathered from members through formal research interviews, hospital admission records, imaging reports, laboratory data.Of the seven disease, five had I disorder, one unipolar depression, hyperthymic phenotype. Information was not available on two members.The cosegregation this suggests close proximity between genes disorders. known loci of are regions chromosomes 1 16 that have been previously linked schizophrenia. This may be useful resource positional cloning candidate genes.