Altered Insula Response to Sweet Taste Processing After Recovery From Anorexia and Bulimia Nervosa

• DOI: 10.1176/appi.ajp.2013.11111745
• Publication Date: 2013-06-04T05:49:38Z
• Authors: Tyson A. Oberndorfer; Guido K.W. Frank; Alan N. Simmons; Angela Wagner; Danyale McCurdy; Julie L. Fudge; Tony T. Yang; Martin P. Paulus; Walter H. Kaye
• Keywords: Anorexia nervosa; Overeating; Sucralose

Recent studies suggest that altered function of higher-order appetitive neural circuitry may contribute to restricted eating in anorexia nervosa and overeating bulimia nervosa. This study used sweet tastes interrogate gustatory neurocircuitry involving the anterior insula related regions modulate sensory-interoceptive-reward signals response palatable foods.Participants who had recovered from were studied avoid confounding effects nutritional state. Functional MRI measured brain repeated sucrose sucralose disentangle processing caloric noncaloric tastes. Whole-brain functional analysis was constrained anatomical interest.Relative matched comparison women (N=14), (N=14) significantly diminished elevated hemodynamic right insula. Anterior compared with exaggerated group (lower higher nervosa).The integrates sensory reward aspects taste service homeostasis. One possibility is weight loss occur because a failure accurately recognize hunger signals, whereas could represent an perception signals. reflect calibration content food offer pathway novel more effective treatments.