Baseline Neuropsychiatric Symptoms and the Risk of Incident Mild Cognitive Impairment: A Population-Based Study

• DOI: 10.1176/appi.ajp.2014.13060821
• Publication Date: 2014-04-04T04:30:57Z
• Authors: Yonas E. Geda; Rosebud O. Roberts; Michelle M. Mielke; David S. Knopman; Teresa J.H. Chris...; Vernon S. Pankratz; Bradley F. Boeve; Ondřej Sochor; Eric G. Tangalos; Ronald C. Petersen; Walter A. Rocca
• Keywords: Baseline (sea)

The authors conducted a prospective cohort study to estimate the risk of incident mild cognitive impairment in cognitively normal elderly (aged ≥70 years) individuals with or without neuropsychiatric symptoms at baseline. research was setting population-based Mayo Clinic Study Aging.A classification aging, impairment, and dementia adjudicated by an expert consensus panel based on published criteria. Hazard ratios 95% confidence intervals were computed using Cox proportional hazards model, age as time scale. Baseline Neuropsychiatric Inventory Questionnaire data available for 1,587 persons who underwent least one follow-up visit.The followed (N=365) censoring variables (N=179) median 5 years. Agitation (hazard ratio=3.06, CI=1.89-4.93), apathy ratio=2.26, CI=1.49-3.41), anxiety ratio=1.87, CI=1.28-2.73), irritability ratio=1.84, CI=1.31-2.58), depression ratio=1.63, CI=1.23-2.16), observed initially, increased later impairment. Delusion hallucination did not. A secondary analysis, limited significance small number participants, showed that euphoria, disinhibition, nighttime behaviors significant predictors nonamnestic but not amnestic By contrast, predicted ratio=1.74, CI=1.22-2.47) impairment.An incidence community-dwelling adults had nonpsychotic psychiatric These baseline similar greater magnitude biomarkers (genetic structural MRI) increasing