Neurofunctional Domains Derived From Deep Behavioral Phenotyping in Alcohol Use Disorder

• DOI: 10.1176/appi.ajp.2018.18030357
• Publication Date: 2019-01-04T08:01:38Z
• Authors: Laura E. Kwako; Melanie L. Schwandt; Vijay A. Ramchandani; Nancy Diazgranados; George F. Koob; Nora D. Volkow; Carlos Blanco; David Goldman
• Keywords: Incentive salience; Alcohol use disorder; Dysfunctional family

Objective: The authors evaluated whether three neurofunctional domains proposed to be critical in the addiction cycle, namely, incentive salience, negative emotionality, and executive function, could identified through factor analysis of a deeply phenotyped clinical sample. Methods: Clinical, behavioral, self-report measures addiction, personality, cognition, behavior, exposure early-life stress were collected as part screening natural history study alcohol use disorders 454 individuals representing spectrum disorders. multiple indicators, causes (MIMIC) approach was used identify significant predictors latent factors by analysis. Results: results showed support for both three- four-factor models explain biobehavioral variation this sample participants with disorder control subjects, but three-factor model had best fit indices. With some nuances, including cross-correlation (lack independence) between factors, corresponded function (executive control). MIMIC revealed that sociodemographic variables predicted these factors. Conclusions: These findings suggest correlated are relevant disorder. More work is required validate standardize disorder, extend other addictive disorders, relate variations them predisposition, course, treatment response, neuroimaging data, psychophysical indicators.