Radiological Features of Dialysis Amyloid Spondyloarthropathy

• DOI: 10.1177/039139888901200403
• Publication Date: 2018-04-16T14:51:33Z
• Authors: O. Fiocchi; P.L. Bedani; C. Orzincolo; A. Storari; P.L. Cavazzini; F. Malacarne; A. Farinelli
• Keywords: Spondyloarthropathy; Vertebral column

Nine patients undergoing regular dialytic treatment (RDT) for more than 60 months (mean 125 +/- 33 months) showed clinical and radiological evidence of non-infective destructive spondyloarthropathy (DSA). The cervical spine was the skeletal segment most affected (100% cases). Three were found also to be suffering from discal bone alterations dorsal column, in two other vertebral bodies L4-L5 changed. Typical pictures a narrowing intervertebral spaces with destruction or sclerosis adjacent subchondral bones, erosions body plates cavitations. CT studies altered spines confirmed lesions osteolytic areas condensation at each level. Ligamentous resulting severe disorders spinal statics discovered during autopsy three patients. Histological study disc peridiscal ligaments indicated presence large amyloid deposits containing beta-2-microglobulin (B2-m). It is possible that minor biocompatibility cuprophan membrane dialyzers significant factor responsible hyperproduction B2-m thus osteo-articular deposition new type amyloidosis.