Neurodegenerative Mechanisms in Subacute Sclerosing Panencephalitis

• DOI: 10.1177/08830738020170101101
• Publication Date: 2008-05-04T01:40:33Z
• Authors: Masaharu Hayashi; Nobutaka Arai; Junichi Satoh; Hisaharu Suzuki; Kazunobu Katayama; Kimiko Tamagawa; Yoshio Morimatsu
• Keywords: Subacute sclerosing panencephalitis; Neuropathology

Subacute sclerosing panencephalitis is caused by persistent brain infection of mutated measles virus, showing inflammation, neuronal loss, and demyelination. We neuropathologically examined six autopsy cases subacute panencephalitis, using in situ nick end-labeling immunohistochemistry. Both the neurons glial cells cerebral cortex showed immunoreactive nuclei two with disease duration within 2 years, whereas they were confined to demyelinated white matter three ranging from 10 years. The cytoplasm for 8-hydroxy-2'-deoxyguanosine 8-hydroxyguanosine, markers oxidative damage DNA ribonucleic acid, respectively, 9 In contrast, 4-hydroxy-2-nonenal-modified proteins, products lipid peroxidation, deposited matters four longer than long survival, expression glutamate transporters was reduced cortex. It speculated that apoptosis stress can contribute early damage, peroxidation disturbed transport may be related subsequent neurodegeneration.