Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990–2010

• DOI: 10.1177/0960327112440111
• Publication Date: 2012-04-25T02:00:38Z
• Authors: GS Goldman; NZ Miller
• Keywords: Vaccine safety

In this study, the Vaccine Adverse Event Reporting System (VAERS) database, 1990–2010, was investigated; cases that specified either hospitalization or death were identified among 38,801 reports of infants. Based on types vaccines reported, actual number vaccine doses administered, from 1 to 8, summed for each case. Linear regression analysis rates as a function (a) reported and (b) patient age yielded linear relationship with r 2 = 0.91 0.95, respectively. The rate increased linearly 11.0% (107 969) 23.5% (661 2817) 8 decreased 20.1% (154 765) children aged <0.1 year 10.7% (86 801) 0.9 year. ratio (RR) mortality 5–8 1–4 is 1.5 (95% confidence interval (CI), 1.4–1.7), indicating statistically significant increase 3.6% CI, 3.2–3.9%) deaths associated 5.5% 5.2–5.7%) doses. male-to-female RR 1.4 1.3–1.5). Our findings show positive correlation between administered percentage hospitalizations deaths. Since are given millions infants annually, it imperative health authorities have scientific data synergistic toxicity studies all combinations might receive. Finding ways safety should be highest priority.