Risk factors for glioblastoma are shared by other brain tumor types

• DOI: 10.1177/09603271241241796
• Publication Date: 2024-03-23T10:12:07Z
• Authors: Carr J. Smith; Thomas A. Perfetti; Chirayu Chokshi; Chitra Venugopal; J. Wesson Ashford; Sheila K. Singh
• Keywords: 0301 basic medicine; 03 medical and health sciences; Dogs; Brain Neoplasms; Risk Factors; Mutation; Humans; Animals; Glioma; Glioblastoma

The reported risk factors for glioblastoma (GBM), i.e., ionizing radiation, Li-Fraumeni syndrome, Neurofibromatosis I, and Turcot also increase the of other brain tumor types. Risk human GBM are associated with different oncogenic mutation profiles. Pedigreed domestic dogs a shorter nose flatter face (brachycephalic dogs) display relatively high rates glioma formation. genetic profiles canine gliomas idiosyncratic. association putatively mutational patterns in humans canines suggests that pathways can result Strong epidemiological evidence an between exposure to chemical carcinogens increased development is currently lacking. Ionizing radiation induces point mutations, frameshift double-strand breaks, chromosomal insertions or deletions. Mutational exposures overlap broad seen radiation. Weak statistical associations epidemiology studies biologically plausible. Molecular approaches comparing reproducible spontaneous analogous found GBMs resected from patients known significant potentially carcinogenic chemicals address difficulties presented by traditional assessment.