Antibodies to M-type phospholipase A2 receptor (PLA2R) in membranous lupus nephritis

• DOI: 10.1177/0961203319828521
• Publication Date: 2019-02-14T04:47:27Z
• Authors: E Garcia-Vives; C Solé; T Moliné; A M Alvarez-Rios; M Vidal; I Agraz; J Ordi-Ros; J Cortés-Hernández
• Keywords: Membranous Nephropathy; Nephritis

Background Antibodies to M-type phospholipase A2 receptor (a-PLA 2 R) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence lupus nephritis (MLN) is still unclear. The objective of this study was assess a-PLA R antibodies a large cohort nephritis. Methods were measured by ELISA serum from systemic erythematosus ( n = 190), whom 37 had biopsy-proven MLN. Positive samples confirmed commercial kit, Western blot and immunohistochemistry renal tissue. Results A total 10 190 (5.3%) circulating in-house assay. detected 7 MLN (18.9%) 3 non-renal disease (3.2%). PLA staining kidney biopsy 5 (71.4%) levels associated active not proteinuria levels. Presence at baseline worse remission rates longer time compared those serologically negative. Conclusions can be low patients, their detection prognosis.