Improvement of hand dexterity following motor cortex rTMS in multiple sclerosis patients with cerebellar impairment

• DOI: 10.1177/1352458508088710
• Publication Date: 2008-06-24T00:35:46Z
• Authors: G Koch; S Rossi; C Prosperetti; C Codecà; F Monteleone; L Petrosini; G Bernardi; D Centonze
• Keywords: Adult; Male; Multiple Sclerosis; Cerebellar Ataxia; Movement; Motor Cortex; cerebellum; motor functions; multiple sclerosis; rtms; transcranial magnetic stimulation; Relapsing-Remitting; Middle Aged; Hand; Transcranial Magnetic Stimulation; Settore MED/26 - NEUROLOGIA; 03 medical and health sciences; Movement; Multiple Sclerosis, Relapsing-Remitting; Male; Cerebellum; Cerebellar Ataxia; Motor Cortex; Middle Aged; Female; Hand; Transcranial Magnetic Stimulation; Adult; Humans; Multiple Sclerosis, Relapsing-Remitting; 0302 clinical medicine; Cerebellum; Humans; Female

We tested the effects of 5-Hz repetitive transcranial magnetic stimulation (rTMS) over motor cortex in multiple sclerosis (MS) subjects with cerebellar symptoms. rTMS improved hand dexterity patients ( n = 8) but not healthy 7), as detected by a significant transient reduction time required to complete nine-hole pegboard task. may be useful approach treat impairment MS patients.