Neurofilament light as a prognostic marker in multiple sclerosis

• DOI: 10.1177/1352458509359725
• Publication Date: 2010-01-20T01:47:20Z
• Authors: Jonatan Salzer; Anders Svenningsson; Peter Sundström
• Keywords: Neurofilament

Relapsing-remitting multiple sclerosis has a variable prognosis and lacks reliable laboratory prognostic marker. Our aim in this study was to investigate the association between neurofilament light levels cerebrospinal fluid early disease severity at long-term follow-up. Neurofilament collected diagnostic lumbar puncture were measured 99 cases. Clinical data obtained from 95 out of those follow-up visits made 14 years (range 8—20 years) after onset. Significant correlations score found for all cases ( r = 0.30, p 0.005), relapsing-remitting 0.47, < 0.001) with recent relapse 0.60, 0.001). In multivariate logistic regression analysis, >386 ng/L (median value detectable levels) increased risk severe fivefold (odds ratio 5.2, 95% confidence interval 1.8—15). Kaplan—Meier analysis showed that conversion secondary-progressive more likely than <60 0.01) or 60—386 0.03). We conclude elevated associated unfavourable prognosis. These suggest level could be used as marker sclerosis.