Number of circulating endothelial progenitor cells as a marker of vascular endothelial function for type 2 diabetes

• DOI: 10.1177/1358863x10367537
• Publication Date: 2010-05-29T00:48:44Z
• Authors: Yun-fei Liao; Lu-Lu Chen; Tian-shu Zeng; Yu-ming Li; Fan Yu; Li-jun Hu; Ling Yue
• Keywords: Endothelial progenitor cell; Endothelial Dysfunction; Brachial artery; Pathogenesis; Surrogate endpoint

Vascular endothelial dysfunction is an early marker of atherosclerosis seen in type 2 diabetes (T2DM). Circulating progenitor cell (EPC) involved the neovasculogenesis and maintenance vascular homeostasis, whose impairment may have important role pathogenesis diabetic vasculopathy. This study was performed to investigate relationship between function circulating EPC number T2DM. A total 46 newly diagnosed T2DM patients (DM group) 51 healthy subjects (NG were recruited. Metformin administered all for 16 weeks. Endothelial assessed by flow-mediated brachial artery dilatation (FMD). defined CD45 low /CD34 + /VEGFR2 quantified flow cytometry. The DM group significantly lower than that NG ( p < 0.001), improved markedly after treatment 0.001). results FMD consistent with variations among three groups In multivariate regression analysis, independent risk factor at baseline 0.05). absolute changes showed significant correlation before r = 0.63, demonstrated related could be considered as a surrogate biological