Bioavailability of Fluoride in Drinking Water: a Human Experimental Study

• DOI: 10.1177/154405910508401104
• Publication Date: 2009-01-09T00:39:42Z
• Authors: A. Maguire; F.V. Zohouri; J.C. Mathers; I.N. Steen; P.N. Hindmarch; P.J. Moynihan
• Keywords: Hard water

It has been suggested that systemic fluoride absorption from drinking water may be influenced by the type of compound in and hardness. Using a human double-blind cross-over trial, we conducted this study to measure c max , T Area Under Curve (AUC) for plasma F concentration against time, following ingestion naturally fluoridated hard soft waters, artificially reference water. Mean AUC over 0 8 hours was 1330, 1440, 1679, 1566, 1328 ng F•min•mL −1 soft, hard, respectively, with no statistically significant differences among waters AUC, or . Any bioavailability between which is present added artificially, are were small compared large within- between-subject variations absorption. Abbreviations used: F, fluoride; under time; AUC(0-3), time 3 ingestion; AUC(0-8), maximum corrected baseline dose ( i.e., individual waters);