Molecular mechanisms of ferroptosis and its effects on bladder cancer.

• DOI: 10.11817/j.issn.1672-7347.2024.230352
• Publication Date: 2024-02-28
• Authors: Ruijie Li; Yiping Ning; Yacheng Yuan; Xukai Yang

Bladder cancer (BC) is one of the 3 common malignant tumors in urinary system, with high incidence, easy metastasis, poor therapeutic efficacy, and prognosis, which seriously threatens health human. Tumor cells exhibit a strong demand for iron, iron overload can induce ferroptosis, an dependent cell death caused by lipid peroxidation membrane damage. Therefore, ferroptosis has anti-tumor potential. The molecular mechanisms associated abnormalities cellular phospholipid metabolism metabolism, dysregulation antioxidant non-antioxidant systems Xc