Association between transforming growth factor β1 polymorphisms and atrial fibrillation in essential hypertensive subjects

• DOI: 10.1186/1423-0127-17-23
• Publication Date: 2010-04-27T06:15:15Z
• Authors: Yongzheng Wang; Xuwei Hou; Yuliang Li
• Keywords: Biochemistry, medical; Polymorphism, Genetic; Genotype; Endocrinology, Diabetes and Metabolism; Research; Clinical Biochemistry; R; Cell Biology; Middle Aged; Transforming Growth Factor beta1; 03 medical and health sciences; 0302 clinical medicine; Atrial Fibrillation; Hypertension; Medicine; Humans; Pharmacology (medical); Genetic Predisposition to Disease; Codon; Molecular Biology

Abstract

Background The association of TGF β1 polymorphisms and atrial fibrillation (AF) in essential hypertensive (EH) subjects remains unknown. Methods EH subjects with AF (EH+AF+) and sinus rhythm (EH+AF-) were enrolled. The polymorphisms of +869 T → C at codon 10 and + 915 G → C at codon 25, were genotyped. The clinical characteristics including serum TGF β1 levels were detected.

Results The GG genotypes of TGF β1 +915 G → C at codon 25 were more prevalent in subjects from EH+AF+ group than those from EH+AF- group (P = 0.009). The subjects with GG genotype from EH+AF+ group had the highest mean serum TGF β1 level, which was significantly higher than that of GG genotype subjects from EH+AF- group (3.18 ± 0.24 ng/dl vs.2.29 ± 0.14 ng/dl, P < 0.05). Multiple analyses revealed that the TGF β1 GG genotype of +915 G → C at codon 25 presented a 3.09 times higher risk in developing AF in the multivariate model after adjusting for age and gender.

Conclusion The polymorphisms of TGF β1 +915 G → C at codon 25 were associated with occurrence of AF and serum TGF β1 level in EH subjects.