Association between transforming growth factor β1 polymorphisms and atrial fibrillation in essential hypertensive subjects

• DOI: 10.1186/1423-0127-17-23
• Publication Date: 2010-04-27T06:15:15Z
• Authors: Yongzheng Wang; Xuwei Hou; Yuliang Li
• Keywords: Essential hypertension

The association of TGF beta1 polymorphisms and atrial fibrillation (AF) in essential hypertensive (EH) subjects remains unknown. Methods EH with AF (EH+AF+) sinus rhythm (EH+AF-) were enrolled. +869 T --> C at codon 10 + 915 G 25, genotyped. clinical characteristics including serum levels detected.The GG genotypes +915 25 more prevalent from EH+AF+ group than those EH+AF- (P = 0.009). genotype had the highest mean level, which was significantly higher that (3.18 +/- 0.24 ng/dl vs.2.29 0.14 ng/dl, P < 0.05). Multiple analyses revealed presented a 3.09 times risk developing multivariate model after adjusting for age gender.The associated occurrence level subjects.