No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families

• DOI: 10.1186/1471-2350-11-1
• Publication Date: 2010-01-01T07:14:26Z
• Authors: Gao Gao; Zhen-Lin Zhang; Jin-Wei He; Hao Zhang; Hua Yue; Wei-Wei Hu; Jie-Mei Gu; Wen-Zhen Fu; Yun-Qiu Hu; Miao Li; Yu-Juan Liu; Jin-Bo Yu
• Keywords: Human genetics; Association (psychology)

Abstract Background The Wnt/beta-catenin signaling pathway plays an important role in skeletal development. Polymorphisms of frizzled-related protein (FRZB), antagonist this pathway, may generate variations bone mineral density (BMD). In study, we analyzed the association between FRZB genotypes and peak BMD variation spines hips two relatively large samples Chinese female-offspring male-offspring nuclear families. Methods We recruited 1,260 subjects from 401 families 1,296 427 genotyped four tagging single nucleotide polymorphisms (tagSNPs) (rs6433993, rs409238, rs288324, rs4666865) spanning entire gene. SNPs rs288326 rs7775, which are associated with hip osteoarthritis, were not selected study because their low minor allele frequencies (MAFs) people. quantitative transmission disequilibrium test (QTDT) was used to analyze each SNP haplotype female- Results families, found no evidence either or haplotypes spine hip. within-family observed for haplotypes, although a significant total rs4666865 ( P = 0.0299). Conclusion Our results suggest that natural is major contributor variability females males. Because ethnic differences exist, other studies different population required confirm such results.