The IGF1small dog haplotype is derived from Middle Eastern grey wolves

• DOI: 10.1186/1741-7007-8-16
• Publication Date: 2010-03-12T14:17:09Z
• Authors: Melissa M Gray; Nathan B Sutter; Elaine A Ostrander; Robert K Wayne
• Keywords: SNP; Linkage Disequilibrium

A selective sweep containing the insulin-like growth factor 1 (IGF1) gene is associated with size variation in domestic dogs. Intron 2 of IGF1 contains a SINE element and single nucleotide polymorphism (SNP) found all small dog breeds that almost entirely absent from large breeds. In this study, we surveyed sample grey wolf populations to better understand ancestral pattern at particular focus on distribution haplotype its relationship origin dog. We present DNA sequence data confirms absence derived SNP allele intron region wolves further establishes wild canids most Grey haplotypes Middle East have higher diversity suggesting an there. Additionally, PCA phylogenetic analyses suggests closer kinship those Eastern wolves. The both mutation for body post-dates domestication However, because dogs possess these diagnostic mutations, mutations likely arose early history Our results show closely related consistent ancient Thus, concordance past archeological studies, our molecular analysis evolution East. See opinion by Driscoll Macdonald: http://jbiol.com/content/9/2/10