MDM2 polymorphism associated with the development of cervical lesions in women infected with Human papillomavirus and using of oral contraceptives

• DOI: 10.1186/1750-9378-9-24
• Publication Date: 2014-07-18T09:03:55Z
• Authors: Carolina MM Amaral; Katerina Cetkovská; Ana PAD Gurgel; Marcus V Cardoso; Bárbara S Chagas; Sérgio SL Paiva J...; Rita de Cássia Pe...; Jacinto C Silva-Neto; Luiz AF Silva; Maria TC Muniz; Valdir Q Balbino; Antonio C Freitas
• Keywords: 03 medical and health sciences; Infectious Diseases; 0302 clinical medicine; Oncology; Epidemiology; Research Article; 3. Good health

The MDM2 gene is the major negative regulator of p53, a tumor suppressor protein. Single nucleotide polymorphism in promoter region leads to increased expression resulting higher levels This event increases attenuation p53 pathway. Polymorphisms this can interfere regulation cellular proliferation. We evaluated whether SNP309 (rs2278744) associated or not with use oral contraceptive heighten susceptibility development cervical lesions women HPV infected.MDM2 was genotyped total 287 patients using PCR-RFLP technique. results were analyzed by UNPHASED v.3.121 and SNPStats programs.The three groups (SIL, LSIL HSIL) showed no significant differences either genotype allelic frequencies for polymorphisms, except when HSIL compared (p = 0.037; OR 1.81). Furthermore, analysis contraceptives, association found between contraceptives variant high-grade TG 0.019; 2.21) control. When 0.006; 2.27).The study suggest that might be good marker assessing progression HSIL. In addition, they also show alone, did have any effect on lesions. However, may act synergistically infection