Urine VCAM-1 as a marker of renal pathology activity index in lupus nephritis

• DOI: 10.1186/ar3912
• Publication Date: 2012-07-13T18:44:34Z
• Authors: Sandeep Singh; Tianfu Wu; Chun Xie; Kamala Vanarsa; Jie Han; Tina Mahajan; Ho Bing Oei; Chul Ahn; Xin J Zhou; Chaim Putterman; Ramesh Saxena; Chandra Mohan
• Keywords: Renal pathology; Nephritis

Abstract Introduction Although renal pathology is highly predictive of the disease course in lupus nephritis, it cannot be performed serially because its invasive nature and associated morbidity. The goal this study to investigate whether urinary levels CXC ligand 16 (CXCL16), monocyte chemotactic protein-1 (MCP-1) or vascular cell adhesion molecule-1 (VCAM-1) patients with nephritis are particular features biopsies obtained on day urine procurement. Methods CXCL16, MCP-1, VCAM-1 were measured samples from 74 13 healthy volunteers. Of enrolled, 24 had a concomitant kidney biopsy at time collection. In addition, other diatheses also included as controls. Results All three molecules elevated systemic erythematosus patients, although (area under curve = 0.92) MCP-1 0.87) best distinguishing controls, most strongly clinical severity active disease. For whom concurrent been performed, exhibited strongest association activity index glomerulonephritis class IV, correlated negatively chronicity index. Interestingly, was anti-neutrophil cytoplasmic antibodies-associated glomerulonephritis, focal segmental glomerulosclerosis membranous nephropathy but not minimal-change Conclusion Urinary emerges reliable indicator activity:chronicity ratios that mark underlying nephritis. Since involved acute phase inflammation when leukocytic infiltration ongoing, longitudinal studies warranted establish tracking may help monitor pathological over time.