Characterization of new bone formation in gout: a quantitative site-by-site analysis using plain radiography and computed tomography

• DOI: 10.1186/ar3913
• Publication Date: 2012-07-13T18:19:54Z
• Authors: Nicola Dalbeth; Aaron Milligan; Anthony J Doyle; Barnaby Clark; Fiona M McQueen
• Keywords: Ankylosis; Tophus

Radiographic descriptions of gout have noted the tendency to hypertrophic bone changes. The aim this study was characterize features new formation (NBF) in gout, and determine relationship between NBF other radiographic disease, particularly erosion tophus. Paired plain radiographs (XR) computed tomography (CT) scans 798 individual hand wrist joints from 20 patients with were analyzed. Following a structured review separate set images, films scored for presence following NBF: spur, osteophyte, periosteal NBF, ankylosis sclerosis. most frequent forms sclerosis osteophyte. Spur less common, rare. On both XR CT, more likely NBF; if present, odds ratios (OR) 45.1 3.3 16.6 26.6 32.3 sclerosis, P all < 0.01. Similarly, on intraosseous tophus OR 48.4 14.5 35.1 39.1 sclerosis; 0.001. This detailed quantitative analysis has demonstrated that occurs frequently affected by gout. work suggests connection loss, tophus, during process joint remodelling