Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker - longitudinal relationships with pain and structural changes: data from the Osteoarthritis Initiative

• DOI: 10.1186/ar4292
• Publication Date: 2013-09-11T08:37:11Z
• Authors: Jeffrey B Driban; Lori Lyn Price; Grace H Lo; Jincheng Pang; David J Hunter; Eric Miller; Robert J Ward; Charles B Eaton; John A Lynch; Timothy E McAlindon
• Keywords: Knee pain

Abstract Introduction Bone marrow lesion (BML) size may be an important imaging biomarker for osteoarthritis-related clinical trials and reducing BML therapeutic goal. However, data on the interrelationships between size, pain, structural progression are inconsistent rarely examined in same cohort. Therefore, we evaluated cross-sectional longitudinal associations of volume with knee pain joint space narrowing (JSN). Methods A assessment was performed magnetic resonance images collected at 24- 48-month Osteoarthritis Initiative visits from a convenience sample 404 participants During visits, assessed WOMAC scores radiographs were acquired scored JSN. summed to generate total index tibiofemoral compartment (compartment greater baseline JSN). Primary analyses included multiple linear regressions (outcome = predictor volume) logistic JSN, volume). Results This 49% female mean age 63 (9.2 standard deviation (SD)) years, 71% had radiographic osteoarthritis study knee. Larger BMLs associated ( P 0.01), presence JSN (odds ratio (OR) 1.50, 95% confidence interval (CI) 1.23 1.83), (OR 1.27, 95%CI 1.11 1.46). Changes positive association changes severity 0.004) this driven by knees that progressing no or small larger BMLs. In contrast, found relationship change progression. Instead, regression medial compared minimal 3.36, 1.55 7.28). follow-up indicated primarily influenced volume. Conclusion Large baseline, disease Additionally, is decreased but not reduced risk concurrent