Roles of mast cells in the pathogenesis of inflammatory myopathy

• DOI: 10.1186/ar4512
• Publication Date: 2014-03-17T16:02:17Z
• Authors: Masaya Yokota; Kotaro Suzuki; Koji Tokoyoda; Kazuyuki Meguro; Junichi Hosokawa; Shigeru Tanaka; Kei Ikeda; Takashi Mikata; Toshinori Nakayama; Hitoshi Kohsaka; Hiroshi Nakajima
• Keywords: Pathogenesis; Experimental pathology

In addition to the pivotal roles of mast cells in allergic diseases, recent data suggest that play crucial a variety autoimmune responses. However, their pathogenesis skeletal muscle diseases have not been clarified despite distribution muscle. Therefore, objective this study is determine development diseases.The number affected was examined patients with dermatomyositis (DM) or polymyositis (PM). The susceptibility cell-deficient WBB6F1-Kit(W)/Kit(Wv) mice (W/W(v) mice) murine model polymyositis, C protein-induced myositis (CIM), compared wild-type (WT) mice. effect cell reconstitution bone marrow-derived (BMMCs) on W/W(v) CIM also evaluated.The increased PM as DM. exhibited significantly reduced disease incidence and histological scores WT CD8⁺ T macrophages muscles decreased Engraftment BMMCs restored Vascular permeability elevated but upon induction.Mast are involved inflammatory myopathy.