Postoperative plasma concentrations of procalcitonin after different types of surgery

• DOI: 10.1186/cc170
• Publication Date: 2009-09-10T14:25:29Z
• Authors: M Meisner; K Tschaikowsky; A Hutzler; C Schick; J Schmidt
• Keywords: Procalcitonin

Background: Whole body hyperthermia induced by radiative systems has been used in therapy of malignant diseases for more than ten years.Von Ardenne and co-workers have developed the 'systemiche Krebs-Mehrschritt-Therapic' (sKMT), a combined regime including whole 42°C, hyperglycaemia relative hyperoxaemia with additional application chemotherapy.This concept employed phase I/II clinical study patients metastatic colorectal carcinoma at Virchow-Klinikum since January 1997.Methods: The sKMT was performed eleven times under intravenous general anaesthesia, avoiding volatile anaesthetics.Core temperatures up to 42°C were reached stepwise warming infrared-A-radiation (IRATHERM 2000®).During procedure blood glucose levels 380-450 mg/dl maintained as well PaO 2 above 200 mmHg.Extensive invasive monitoring all measurements REF-Ox-Pulmonary artery catheter continuous measuring mixed venous saturation (Baxter Explorer®) arterial pressure.Data calculation hemodynamic gas exchange parameters collected four times, 37°C, 40°C, 41.8-42°C 39°C, during FiO 1.0 times.Fluids given order keep central-venous Wedge pressure within normal range procedure.Statistics using Wilcoxon Test.Results: Statistically significant differences found between heart rate, cardiac index systemic vascular resistance comparing data 37°C 42°C.Heart rate increased maximum (P < 0.0001) whereas had its minimum 0.0001).Mean dropped increasing temperature, not significant.Calculation stroke volume ventricular volumes showed only slight decrease endsystolic resulting right ejection fraction marginally = 0.038) baseline.Right work mean pulmonary 0.0115 P 0.0037), little compared resistance, left even though showing no difference.Values oxygen did vary therapy, right-left shunt temperature associated increase 0.0323) 42°C.Conclusion: Under function patients, who do any pre-existing impairment, can be almost unchanged, ie pressure, despite an