Effect of nattokinase supplementation on plasma fibrinogen levels, whole blood viscosity and mortality in experimental sepsis in rats

• DOI: 10.1186/cc7501
• Publication Date: 2009-03-13T19:17:56Z
• Authors: M Cengiz; M Yilmaz; A Ramazanoglu; S Ozdem; H Meiselman; O Baskurt
• Keywords: Nattokinase; Plasma viscosity

Introduction There is considerable uncertainty about the reproducibility of various instruments used to measure dyspnea, their ability reflect changes in symptoms, whether they accurately patient's experience and if its evolution similar between acute heart failure syndrome patients nonacute patients.URGENT was a prospective multicenter trial designed address these issues.Methods Patients were interviewed within 1 hour first physician evaluation, emergency department or care setting, with dyspnea assessed by patient using both five-point Likert scale 10-point visual analog (VAS) sitting (60º) then supine (20º) position had not been considered severe very versus decubitus measurement.Results Very good agreements found VAS at baseline (0.891, P <0.0001) (from 6) (0.800, (AHF) patients.Lower when from H6 measured compared seven-point comparative (0.512 0.500 respectively) AHF patients.The worse admission, greater amplitude improvement 6 hours; this relationship stronger (Spearman's rho coefficient = 0.672) than (0.272) (both patients.By Likert, only nine (3% (1% 5%)) reported an 177 (51% (46% 57%)) no change, 159 (41% 52%)) up PDA test markedly different non-AHF patients.Conclusions Both clinical tools showed agreement tests performed hours later patients.Dyspnea improved more threequarters regardless tool change dyspnea.The hours. P2