Changes in S-100 protein serum levels in survivors of out-of-hospital cardiac arrest treated with mild therapeutic hypothermia: a prospective, observational study

• DOI: 10.1186/cc7785
• Publication Date: 2009-04-16T06:13:19Z
• Authors: Matthias Derwall; Christian Stoppe; David Brücken; Rolf Rossaint; Michael Fries
• Keywords: Male; Emergency Medical Services; Research; S100 Proteins; Observation; Middle Aged; Critical Care and Intensive Care Medicine; Cardiopulmonary Resuscitation; Heart Arrest; 3. Good health; Hypothermia, Induced; Germany; Humans; Female; Prospective Studies; Survivors; Aged

Knowledge about the influence of current neuroprotective interventions on prognostic markers after survival from cardiac arrest is lacking. This study aimed to investigate effects mild therapeutic hypothermia release astroglial protein S-100 cardiopulmonary resuscitation (CPR) in survivors out-of-hospital arrest. was a prospective, observational performed during two-year period, involving medical emergency services and five collaborating hospitals at city Aachen, Germany. Sixty-eight subjects were enrolled by physician duty taking blood samples successful attempts with return spontaneous circulation (ROSC), followed 6, 12, 24, 72 120 hours post ROSC appropriate intensive care unit staff. Depending decision attending physician, cooled down 33°C (n = 37) for 24 or held 37°C 31). Patients tracked estimating mortality gross neurological outcome 14 days. levels patients not receiving (normothermia (NT)) showed equivalent numbers as compared (mild (MTH)) baseline (NT 1.38 μg/l versus MTH 1.30 μg/l; P 0.886). significantly lower good days event comparison their peers adverse (P 0.014). Although difference favourable reached statistical significance, it did NT patients. predictive power best admission but later time points, had no serum non-traumatic particular setting this investigation.