A low dose of curcumin-PDA nanoparticles improves viability and proliferation in endoneurial fibroblasts and Schwann cell cultures

• DOI: 10.1186/s11671-024-04023-7
• Publication Date: 2024-05-07T16:01:47Z
• Authors: Lucia Vázquez Alb...; Marcela Martínez-...; Eloisa Arrarte; Carolina Echeverry; Miguel Calero; Alejandra Kun
• Keywords: Schwann cell; Viability assay

Curcumin is a polyphenol extracted from Curcuma longa's roots. Low doses of curcumin are related to anti-inflammatory, antioxidant, and neuroprotective effects, while high used for their lethality. This diversity behaviors allows us understand as compound with hormetic action. Due its strongly hydrophobic character, often solubilized in organic compounds. In this way, we have recently reported the undesirable occasionally irreversible effects alcohol DMSO on viability primary Schwann cell cultures. scenario, use nanoparticles delivery systems has become successful alternative strategy these present work, describe structure Polydopamine (PDA) nanoparticles, loaded low dose (Curc-PDA) without additional solvents. We analyzed released, found two different forms curcumin. Small increased proliferation were observed endoneurial fibroblast cultures when Curc-PDA was steadily supplied 5 days. The bioavailability natural impact cells culture not only confirm properties at very but also provide glimpse possible therapeutic PNS conditions which SCs involved.