A novel transdermal drug delivery system: drug-loaded ROS-responsive ferrocene fibers for effective photoprotective and wound healing activity

• DOI: 10.1186/s11671-024-04058-w
• Publication Date: 2024-07-29T14:03:52Z
• Authors: Sangwoo Kim; Yoon Kim; Chaehyun Kim; Won Il Choi; Byoung Soo Kim; Jinkee Hong; Hoik Lee; Daekyung Sung
• Keywords: Transdermal patch; Electrospinning

Abstract The present study proposes an innovative transdermal drug delivery system using ferrocene-incorporated fibers to enhance the bioavailability and therapeutic efficacy of ascorbyl tetraisopalmitate. Using electrospinning technology, authors created ferrocene polymer capable highly efficient encapsulation controlled release in response reactive oxygen species commonly found wound sites. approach improves upon previous methods significantly by offering higher loading capacities sustained release, directly targeting diseased cells. results confirm potential for localized delivery, potentially reducing side effects increasing patient convenience. method could facilitate application bioactive compounds medical textiles targeted therapy.