Prenatal exposure to bisphenol A and phthalates and behavioral problems in children at preschool age: the Hokkaido Study on Environment and Children’s Health

• DOI: 10.1186/s12199-018-0732-1
• Publication Date: 2018-09-07T16:35:28Z
• Authors: Machiko Minatoya; Sachiko Itoh; Keiko Yamazaki; Atsuko Araki; Chihiro Miyashita; Naomi Tamura; Jun Yamamoto; Yu Onoda; Kazuki Ogasawara; Toru Matsumura; Reiko Kishi
• Keywords: Cotinine

Studies reported adverse behavioral development including internalizing and externalizing problems in association with prenatal exposure to bisphenol A (BPA) phthalates; however, findings were not sufficient due using different assessment tools child ages among studies. This study aimed examine associations between maternal serum levels of BPA phthalate metabolites at preschool age.The Strengths Difficulties Questionnaire (SDQ) was used assess 5 years age. metabolite the first trimester determined by LC-MS/MS for 458 children. Variables adjustment parental ages, cotinine levels, family income during pregnancy, sex, birth order, age SDQ completed.The median concentrations BPA, MnBP, MiBP, MEHP, MECPP, primary secondary phthalates, 0.062, 26.0, 7.0, 1.40, 0.20 ng/ml, respectively. MECPP level associated increase conduct problem risk (OR = 2.78, 95% CI 1.36-5.68) overall remained after sex stratification, odds ratios increased wider confidence interval 2.85, 1.07-7.57 boys, OR 4.04, 1.31-12.5 girls, respectively). ∑DBPm (MnBP + MiBP), ∑DEHPm (MEHP+MECPP) any problems.Our analyses found no significant or summation but suggested possible problems.