Hokkaido birth cohort study on environment and children’s health: cohort profile 2021

• DOI: 10.1186/s12199-021-00980-y
• Publication Date: 2021-05-22T13:02:53Z
• Authors: Reiko Kishi; Atsuko Ikeda-Araki; Chihiro Miyashita; Sachiko Itoh; Sumitaka Kobayashi; Yu Ait Bamai; Keiko Yamazaki; Naomi Tamura; Machiko Minatoya; Rahel Mesfin Ketema; Kritika Poudel; Ryu Miura; Hideyuki Masuda; Mariko Itoh; Takeshi Yamaguchi; Hisanori Fukunaga; Kumiko Ito; Houman Goudarzi
• Keywords: Male; 490; 610; Review Article; Growth; Development; Genetic polymorphisms; Early life; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; Japan; Pregnancy; Hypersensitivity; Humans; Allergies andinfectious diseases; Child; 2. Zero hunger; DOHaD; Child Health; Infant; Environmental Exposure; Fetal Blood; Birth size; Hormones; 3. Good health; Environmental chemicals; Secular trend; Neurodevelopmental Disorders; 13. Climate action; Child, Preschool; Prenatal Exposure Delayed Effects; Epigenetics; Environmental Pollutants; Female; Public aspects of medicine; RA1-1270; Environmental Health; Biomarkers; Follow-Up Studies

Abstract Background The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of two birth cohorts different population sizes: the Sapporo cohort cohort. Our primary objectives are to (1) examine effects that low-level environmental chemical exposures have outcomes, including defects growth retardation; (2) follow development allergies, infectious diseases, neurobehavioral developmental disorders, as well perform a longitudinal observation child development; (3) identify high-risk groups based genetic susceptibility chemicals; (4) additive various chemicals, tobacco. Methods purpose this report provide update progress Study, summarize recent results, suggest future directions. In particular, provides latest details from questionnaire surveys, face-to-face examinations, collection biological specimens children measurements their exposures. Results findings indicate risk factors parental characteristics outcomes mediating effect between socioeconomic status small for gestational age. Maternal serum folate was not associated with defects. Prenatal exposure smoking were size growth, cord blood biomarkers, such adiponectin, leptin, thyroid, reproductive hormones. We also found significant associations levels neuro development, asthma, allergies. Conclusions Chemical can occur both before after birth. Longer follow-up crucial in studies reinforce Developmental Origins Disease hypothesis. contrast, considering shifts due regulation essential, which may change association health outcomes. This individual adverse depends genotype. Epigenome modification DNA methylation discovered, indicating necessity examining molecular biology perspectives. International collaborations add new dimension current knowledge novel discoveries future.