Role of serum cathelicidin in diagnosis of patient with prostatitis and prostate carcinoma

• DOI: 10.1186/s12301-022-00330-6
• Publication Date: 2022-12-03T06:03:21Z
• Authors: Necla Benlier; Mehmet Solakhan; Özlem Nuray Sever; Zeliha Yıldırım; Nuri Orhan; Hülya Çiçek; Mustafa Yıldırım
• Keywords: Cathelicidin

Abstract Background This study investigated the diagnostic role of 75 levels measured in serum prostatitis and prostate carcinoma differentiation these two conditions. Methods The was conducted with patients histopathologically diagnosed or followed up at Departments Urology Medical Oncology 21 healthy male subjects. Serum cathelicidin were using ELISA method. Statistical analyses performed SPSS for Windows 22.0 package software. Compliance variables to normal distribution examined visual analytic methods. In Kolmogorov–Smirnov test, cases a p value greater than 0.05 accepted as distribution. Results A total including 45 30 prostatitis, well control subjects included study. Prostate-specific antigen (PSA) detected 23 (4–1200) ng/mL 9.85 (3.9–405 ng/mL) prostatitis. diagnostically significant when assessed by ROC analysis cancer, groups ( = 0.005). cutoff values derived from curve 3.5151 distinguishing cancer 2.2620 versus group 1.2340 group. Conclusions this we showed that significantly higher carcinoma. Measurement could be used marker facilitating differential diagnosis strengthen suspicion before biopsy distinguish cases.