Expression and structural analysis of taste receptor genes in Iberian and Duroc pigs

• DOI: 10.1186/s12711-025-00968-0
• Publication Date: 2025-05-02T11:04:07Z
• Authors: Cristina Óvilo; Rita Benítez; Yolanda Núñez; Ramón Peiró-Pastor; Fabian García; Eduardo De Mercado; Emilio Gómez-Izqu...; Juan García-Casco; Clemente López-Bote; María Muñoz
• Keywords: Umami; Taste receptor; CD36; Nutrigenomics; Lingual papilla

Abstract Background Taste receptor genes are expressed in sensory cells located the tongue and influence food preferences, voluntary feed intake, other relevant traits. perception may differ between livestock breeds that show differences eating behaviour animals receive different diets or phenotypic variation intake related-traits. The objectives of this work were to deepen understanding regulation function taste circumvallate papillae obese Iberian pigs comparison Duroc pigs, characterize their genetic associations with production Results We performed a gene expression structural analysis ten pigs. Gene was quantified 48 growing maintained under identical management conditions but fed isocaloric differing energy source: either high concentration fat rich oleic acid (HO) carbohydrates (CH); sacrificed after 47 days treatment (50.5 kg live weight). differed two for most analyzed genes, TAS1R1, TAS1R2, TAS1R3 , TAS2R4 TAS2R38 TAS2R39 GPR84, CD36 being overexpressed diet effect modulated by breed, TAS1R1 TAS1R3, only HO diet. Detection variants (single nucleotide polymorphisms, SNPs) panel on muscle RNA-seq data, three SNPs selected association studies. All associated various growth, fattening, tissue content, composition Moreover, CD36:c.910G/T SNP oral predicted mRNA secondary structure. Conclusions Most at lower level from than This aligns overall sensitivity, higher nature Significant results observed meat quality traits liver composition, which showed segregation world-wide distributed breeds, particularly potential causal gene, growth segregates populations.