Mutational Signatures in Cancer (MuSiCa): a web application to implement mutational signatures analysis in cancer samples
QH301-705.5
Shiny
Computer applications to medicine. Medical informatics
Mutational signatures
R858-859.7
Web Browser
COSMIC database
Web tool
R language
03 medical and health sciences
Neoplasms
Databases, Genetic
Cancer genomics
Humans
Biology (General)
0303 health sciences
Genome, Human
Computational Biology
Genetic Variation
3. Good health
Single nucleotide variants
Mutation
Transcriptome
Software
Genes, Neoplasm
DOI:
10.1186/s12859-018-2234-y
Publication Date:
2018-06-14T01:43:01Z
AUTHORS (6)
ABSTRACT
Mutational signatures have been proved as a valuable pattern in somatic genomics, mainly regarding cancer, with potential application biomarker clinical practice. Up to now, several bioinformatic packages address this topic developed different languages/platforms. MutationalPatterns has arisen the most efficient tool for comparison currently reported Catalogue of Somatic Mutations Cancer (COSMIC) database. However, analysis mutational is nowadays restricted small community experts. In work we present Signatures (MuSiCa), new web based on and built using Shiny framework R language. By means simple interface suited non-specialized researchers, it provides comprehensive status supplied cancer samples. It permits characterizing profile burden mutations, well quantifying COSMIC-reported signatures. also allows classifying samples according above signature contributions. MuSiCa helpful characterize accessible online at http://bioinfo.ciberehd.org/GPtoCRC/en/tools.html source code freely available https://github.com/marcos-diazg/musica .
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