Identification of genomic regions associated with feed efficiency in Nelore cattle

• DOI: 10.1186/s12863-014-0100-0
• Publication Date: 2014-09-25T11:44:50Z
• Authors: Priscila SN de Ol...; Aline SM Cesar; Michele L do Nasc...; Amália S Chaves; Polyana C Tizioto; Rymer R Tullio; Dante PD Lanna; Antonio N Rosa; Tad S Sonstegard; Gerson B Mourao; James M Reecy; Dorian J Garrick; Maurício A Mudadu; Luiz L Coutinho; Luciana CA Regitano
• Keywords: Residual feed intake; Beef Cattle

Feed efficiency is jointly determined by productivity and feed requirements, both of which are economically relevant traits in beef cattle production systems. The objective this study was to identify genes/QTLs associated with components Nelore using Illumina BovineHD BeadChip (770 k SNP) genotypes from 593 steers. analyzed included: average daily gain (ADG), dry matter intake (DMI), feed-conversion ratio (FCR), (FE), residual (RFI), maintenance (ME), (EG), partial growth (PEG) relative rate (RGR). Bayes B analysis completed Gensel software parameterized fit fewer markers than animals. Genomic windows containing all the SNP loci each 1 Mb that accounted for more 1.0% genetic variance were considered as QTL region. Candidate genes within explained 1% selected putative function based on DAVID Gene Ontology. Thirty-six (1-Mb window) identified chromosomes 1, 2, 3, 5, 6, 7, 8, 9, 10, 12, 14, 15, 16, 18, 19, 20, 21, 22, 24, 25 26 (UMD 3.1). amount individual ranged 0.5% 9.07%. Some these minimally overlapped previously reported Bos taurus. regions described harbor biological functions related metabolic processes, lipid protein metabolism, generation energy growth. Among positional candidate are: HRH4, ALDH7A1, APOA2, LIN7C, CXADR, ADAM12 MAP7. genomic some have not been indicus. Comparison published results indicates different QTLs may be involved control population, compared taurus cattle.