Improved Macaca fascicularis gene annotation reveals evolution of gene expression profiles in multiple tissues

• DOI: 10.1186/s12864-018-5183-y
• Publication Date: 2018-10-31T22:11:15Z
• Authors: Tao Tan; Lin Xia; Kailing Tu; Jie Tang; Senlin Yin; Lunzhi Dai; Peng Lei; Biao Dong; Hongbo Hu; Yong Fan; Yang Yu; Dan Xie
• Keywords: Model Organism; Gene Annotation

Macaca fascicularis (M. fascicularis) is a primate model organism that played important role in studying human health. It vital to better understand the similarity and differences of gene regulation between M. human. Current comparative study two species are limited by low quality annotation lack regulatory element data on genome. In this study, we improved with 57 expression from multiple tissues and, more importantly, manual curation procedure. The new enabled us map identify location accurately. Comparing same cell types, characterized evolution patterns homologous genes.