Differential effects of coconut versus soy oil on gut microbiota composition and predicted metabolic function in adult mice

• DOI: 10.1186/s12864-018-5202-z
• Publication Date: 2018-11-07T13:39:28Z
• Authors: Vania Patrone; Andrea Minuti; Michela Lizier; Francesco Miragoli; Franco Lucchini; Erminio Trevisi; Filippo Rossi; Maria Luisa Calle...
• Keywords: Akkermansia muciniphila; Coconut oil; Diet-induced obese; Lactobacillus reuteri; Akkermansia

Animal studies show that high fat (HF) diet-induced gut microbiota contributes to the development of obesity. Oil composition high-fat diet affects metabolic inflammation differently with deleterious effects by saturated fat. The aim present study was examine diversity and capacity cecal bacterial community in C57BL/6 N mice administered two different diets, enriched respectively coconut oil (HFC, fat) or soy (HFS, polyunsaturated fat). relative impact each hypercaloric evaluated after 2 8 weeks feeding, compared a low-fat, control (LF).The HFC induced same body weight gain storage as HFS diet, but produced higher plasma cholesterol levels treatment. At time point, diet-fed characterized an increased abundance Allobaculum, Anaerofustis, F16, Lactobacillus reuteri Deltaproteobacteria, decreased Akkermansia muciniphila mice. Comparison fed versus indicated major changes were shared between including increase plantarum, Lutispora, Syntrophomonas, while some other shifts specifically associated either oil. Prediction gene functions showed depleted pathways involved fatty acid metabolism, amino xenobiotic degradation metabolism terpenoids polyketides on diet. Correlation analysis revealed remarkable relationships compositional alterations transcriptomic phenotypes mice.The highlights significant differences predictive consuming vs correlations established specific taxa various traits linked host lipid energy give insights into role functioning may contribute disorders.