Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model

• DOI: 10.1186/s12866-015-0400-1
• Publication Date: 2015-03-20T03:51:11Z
• Authors: Rebeca Martín; Sylvie Miquel; Florian Chain; Jane M Natividad; Jennifer Jury; Jun Lu; Harry Sokol; Vassilia Theodorou; Premysl Bercik; Elena F Verdu; Philippe Langella; Luis G Bermúdez-H...
• Keywords: Faecalibacterium prausnitzii; Dysbiosis; Intestinal Permeability; Proinflammatory cytokine

The human gut houses one of the most complex and abundant ecosystems composed up to 10(13)-10(14) microorganisms. importance this intestinal microbiota is highlighted when a disruption ecosystem equilibrium appears (a phenomenon called dysbiosis) leading an illness status, such as inflammatory bowel diseases (IBD). Indeed, reduction commensal bacterium Faecalibacterium prausnitzii (one prevalent bacterial species in healthy adults) has been correlated with several diseases, including IBD, importantly, it shown that anti-inflammatory protective effects pre-clinical models colitis. Some dysbiosis disorders are characterized by functional physiological alterations. Here, we report beneficial F. changes induced chronic low-grade inflammation murine model. Chronic dysfunction were mice two episodes dinitro-benzene sulfonic acid (DNBS) instillations. Markers inflammation, permeability, colonic serotonin cytokine levels studied. strain A2-165 its culture supernatant (SN) then investigated.No significant differences observed classical markers confirming was subclinical. However, cytokines IL-6, INF-γ, IL-4 IL-22 higher DNBS-treated than untreated mice. Importantly, treated either or SN exhibited decreases tissue levels.Our results show had on epithelial barrier impairment These observations confirm potential novel probiotic treatment management inflammation.