Detection and characterization of carbapenem resistant Gram‐negative bacilli isolates recovered from hospitalized patients at Soba University Hospital, Sudan
Aztreonam
Nitrofurantoin
Carbapenem
Trimethoprim
Sulfamethoxazole
DOI:
10.1186/s12866-021-02133-1
Publication Date:
2021-05-04T07:03:09Z
AUTHORS (12)
ABSTRACT
Abstract Background Antimicrobial resistance (AMR) poses a complex threat to global health security and universal coverage. Recently, nosocomial infections with carbapenemase-producing Gram-negative bacilli (GNB) is increasing worldwide. We report the molecular characterization detection of genes associated carbapenemase producing Gram negative bacteria isolated from hospitalized patients at Soba University Hospital (SUH) in Khartoum State, Sudan. Results Between October 2016 February 2017, total 206 GNB clinical specimens were collected SUH. Of carbapenem isolates, 171 (83 %) confirmed as phenotypically resistant 121 (58.7 isolates harboured one or more genes. New Delhi metallo-β-lactamase (NDM) types most predominant genes, bla NDM 107(52 %), followed by IMP 7 (3.4 OXA-48 5(2.4 VIM 2 (0.9 %). Co-resistance detected 87 (81.3 all isolates. NDM-1 was frequent subtype observed 75 (70 The highest percentage recorded ampicillin (98 cephalexin (93.5 amoxicillin clavulanic acid (90 cefotaxime (89.7 ceftriaxone (88.4 ceftazidime (84.2 sulfamethoxazole-trimethoprim (78.4 nitrofurantoin (75.2 aztreonam (66 temocillin (64 A close correlation between phenotypic observed. Conclusions frequency found be high prevalent gene among Close surveillance across hospitals Sudan required. relative distribution Africa needs defined.
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