Preoperative dexamethasone for acute post-thoracotomy analgesia: a randomized, double-blind, placebo-controlled study

• DOI: 10.1186/s12871-018-0599-0
• Publication Date: 2018-09-27T17:31:49Z
• Authors: Kyoung-Woon Joung; Hyeong Ryul Kim; Wook-Jong Kim; Ye Ji Lim; Jae Won Kim; Eun-Ho Lee; In-Cheol Choi
• Keywords: Sufentanil; Thoracotomy; Ropivacaine; Bolus (digestion)

The analgesic effects of dexamethasone have been reported previously, and the present study determined preoperative on postoperative pain in patients who received thoracotomy. Forty participated this randomized, double-blind study. All either via a 0.1 mg/kg intravenous bolus before anesthetic induction or an equal volume saline. Postoperative analgesia was provided to both groups epidural patient-controlled (PCA), which consisted 250 μg sufentanil mL ropivacaine (0.18%) for 72 h. primary outcome cumulative consumption PCA at 24 secondary outcomes were intensity scores during resting coughing h, quality recovery, total amount rescue analgesics required, length hospital stay. No significant differences observed between control infusion h (63.6 [55.9–72.7] vs. 68.5 [60.2–89.0] ml, P = 0.281) (199.4 [172.4–225.1] 194.7 [169.1–252.2] 0.890). Moreover, there no difference A single administration period does not reduce opioid post-thoracotomy pain. registered http://cris.nih.go.kr ( KCT0000359 ) conducted from December 2011 October 2012.