Trace of delirium after robotic lower abdominal tumor resection at different end-tidal carbon dioxide: a RCT trial

• DOI: 10.1186/s12871-024-02617-3
• Publication Date: 2024-07-12T07:02:09Z
• Authors: Jingwen Chen; Si Liang; Ming Wei; Yue Ma; Tianpeng Bi; Zheng Liu; Yang Song; Hong Chen; Yu Wang
• Keywords: Male; Adult; End-tidal carbon dioxide; Research; Postoperative delirium; Delirium; Robotic surgery; Carbon Dioxide; Middle Aged; 03 medical and health sciences; Postoperative Complications; 0302 clinical medicine; Robotic Surgical Procedures; Anesthesiology; Abdominal Neoplasms; Humans; RD78.3-87.3; Female; Tumor resection; Aged

Abstract Background Postoperative delirium (POD) often occurs in oncology patients, further increasing the medical and financial burden. Robotic technology lower abdominal tumors resection reduces surgical trauma but increases risks such as carbon dioxide (CO 2 ) absorption. This study aimed to investigate differences their occurrence of POD at different end-tidal CO levels. Method was approved by Ethics Committee Affiliated Hospital He Bei University (HDFY-LL-2022-169). The registered with Chinese Clinical Trials Registry on URL: http://www.chictr.org.cn , Number: ChiCTR2200056019 (Registry Date: 27/08/2022). In patients scheduled robotic tumor from September 1, 2022 December 31, 2022, a comprehensive assessment performed three days postoperatively using CAM scale clinical review records. Intraoperative administration etCO depending randomized grouping after intubation. Group L received level management (31-40mmHg), H maintained higher level(41-50mmHg) during pneumoperitoneum. Data were analyzed Pearson Chi-Square or Wilcoxon Rank Sum tests multiple logistic regression. Preoperative mental status score, alcohol impairment nicotine dependence history hypertension diabetes, duration surgery worst pain score included regression model along basic patient information for covariate correction analysis. Results Among 103 enrolled 19 (18.4%) developed postoperative delirium. incidence groups 21.6% 15.4% H, respectively, no statistical differences. adjusted multivariate analysis, age statistically significant predictors breath-hold test significantly postoperatively, found between two groups. Conclusion With assistant, undergoing not modified management, however, positively associated risk factors.