Semaphorin 3A attenuates cardiac autonomic disorders and reduces inducible ventricular arrhythmias in rats with experimental myocardial infarction

• DOI: 10.1186/s12872-016-0192-8
• Publication Date: 2016-01-19T10:53:13Z
• Authors: Hesheng Hu; Yongli Xuan; Mei Xue; Wenjuan Cheng; Ye Wang; Xinran Li; Jie Yin; Xiaolu Li; Na Yang; Yugen Shi; Suhua Yan
• Keywords: Angiology

To investigate the effects of semaphorin 3A (sema 3A) on cardiac autonomic regulation and subsequent ventricular arrhythmias (VAs) in post-infarcted hearts.In order to explore functions sema hearts, lentivirus-Sema 3A-shRNA negative control vectors were delivered peri-infarcted myocardium rats respectively. Meanwhile, recombinant (0.9% NaCl solution) injected intravenously into infarcted test therapeutic potential 3A. Results indicated that levels higher hearts compared with sham rats. However, silencing leaded sympathetic hyperinnervation, increased myocardial norepinephrine (NE) content inducible VAs. Conversely, intravenous administration reduced nerve sprouting, improved regulation, decreased incidence both infarct size function similar among hearts.The upregulation exerted beneficial infarction-induced disorders by increasing electrical stability reducing Sema might be a agent for abnormalities induced arrhythmias.