Endothelial progenitor cells and plaque burden in stented coronary artery segments: an optical coherence tomography study six months after elective PCI

• DOI: 10.1186/s12872-017-0534-1
• Publication Date: 2017-04-26T02:01:31Z
• Authors: Sylvia Otto; Kristina Nitsche; Christian Jung; Aleh Kryvanos; Andrey Zhylka; Kerstin Heitkamp; Juan-Luis Gutiérr...; Björn Goebel; P. Christian Schulze; Hans R. Figulla; Tudor C. Poerner
• Keywords: Endothelial progenitor cell; Vulnerable plaque; Computed Tomography Angiography

Endothelial progenitor cells (EPC) are involved in neovascularization and endothelial integrity. They might be protective atherosclerosis. Optical coherence tomography (OCT) is a precise intracoronary imaging modality that allows assessment of subintimal plaque development. We evaluated the influence EPC on coronary burden stable disease implemented novel computational analysis algorithm using OCT. Forty-three patients (69.8% males, 69.6 ± 7.7 years) were investigated by OCT during re-angiography 6 months after elective stent implantation. Different subpopulations EPCs identified flow cytometry according to their co-expression antigens (CD34+, CD133+, kinase domain receptor, KDR+). An was applied calculate underlying total stented segments from images. Plaque morphology assessed international consensus imaging. A cumulative sub-strut volume 10.87 12.7 mm3 sub-stent area 16.23 17.0 mm2 found within vessel with no significant differences between different types. All (mean levels: CD34+/CD133+: 2.66 2.0%; CD34+/KDR+: 7.50 5.0%; CD34+/CD133+/KDR+: 1.12 1.0%) inversely correlated (p ≤ 0.012). This for first time comprehensive quantification illustration as spread out charts. Increased levels associated less which adds previous findings role