Early recurrence after cryoballoon versus radiofrequency ablation for paroxysmal atrial fibrillation: mechanism and implication in long-term outcome

• DOI: 10.1186/s12872-022-02816-1
• Publication Date: 2022-09-07T11:05:30Z
• Authors: Yue Wei; Yangyang Bao; Changjian Lin; Yun Xie; Qingzhi Luo; Ning Zhang; Liqun Wu
• Keywords: Cryoablation

Abstract Background Early recurrence (ER) after catheter ablation for atrial fibrillation (AF) has been considered as a common phenomenon but its mechanism and implication in long-term outcome not fully elucidated. We aimed to clarify the relation between post-ablation inflammation ER cryoballoon (CBA) or radio-frequency (RFA) evaluate clinical significance of ER. Methods A total 154 patients with paroxysmal AF undergoing were consecutively recruited, including 90 RFA (RF group) 64 CBA (CB group). Myocardial injury biomarkers analyzed before 6 h, 24 h 48 ablation. Acute early (AER), non-acute (NAER) late (LR) was defined tachyarrhythmia during 0–3, 4–90 days beyond 90-day blanking period Results Cardiac troponin I significantly higher CB group while C reactive protein (CRP) Ratio Neutrophil/Lymphocyte more elevated RF group. Higher CRP level associated AER lower predictive In addition, average cryoablation duration positively correlated Cox regression revealed that NAER left diameter LR group, CBA. Conclusions Post-ablation greater than Excessive inflammatory response may be an important factor RFA. related LR. Further investigations are still warranted address on these findings.